| Catalog_no | AB0640 |
| Product_name | Phospho-mouse p21Cip1(S125) Antibody |
| Category | 抗原抗体 |
| Applications | WB, IHC-P, FC |
| Reactivity | M |
| Size | 100μL/50μL |
| Price | 2000.00/1100.00 |
| immunogen | MOUSE |
| Specificity | This mouse p21Cip1 Antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding S125 of mouse p21Cip1. |
| Source | Rabbit |
| Dilution | DB,1:500; |
| Purification | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by two-step phosphospecific peptide affinity purification. |
| othername | Cyclin-dependent kinase inhibitor 1, CDK-interacting protein 1, Melanoma differentiation-associated protein, p21, Cdkn1a, Cip1, Waf1 |
| Isotype | Rabbit Ig |
| Background | The protein encoded by this gene belongs to the highly
conserved cyclin family, whose members are characterized by a
dramatic periodicity in protein abundance through the cell cycle.
Cyclins function as regulators of CDK kinases. Different cyclins
exhibit distinct expression and degradation patterns which
contribute to the temporal coordination of each mitotic event. This
cyclin forms a complex with and functions as a regulatory subunit
of CDK4 or CDK6, whose activtiy is required for cell cycle G1/S
transition. This protein has been shown to interact with and be
involved in the phosphorylation of tumor suppressor protein Rb. The
CDK4 activity associated with this cyclin was reported to be
necessary for cell cycle progression through G2 phase into mitosis
after UV radiation. Several transcript variants encoding different
isoforms have been found for this gene. |
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