| Catalog_no | AB0706 |
| Product_name | HNMT Antibody |
| Category | 抗原抗体 |
| Applications | IHC-P, IF, WB |
| Reactivity | H |
| Size | 100μL/50μL |
| Price | 2000.00/1100.00 |
| immunogen | HUMAN |
| Specificity | Purified His-tagged HNMT protein(Fragment) was used to produced this monoclonal antibody. |
| Dilution | WB,1:100~1000; |
| Purification | Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS. |
| othername | Histamine N-methyltransferase, HMT, HNMT |
| Isotype | IgG1 |
| Background | In mammals, histamine is metabolized by two major
pathways: N(tau)-methylation via histamine N-methyltransferase and
oxidative deamination via diamine oxidase. This gene encodes the
first enzyme which is found in the cytosol and uses
S-adenosyl-L-methionine as the methyl donor. In the mammalian
brain, the neurotransmitter activity of histamine is controlled by
N(tau)-methylation as diamine oxidase is not found in the central
nervous system. A common genetic polymorphism affects the activity
levels of this gene product in red blood cells. Multiple
alternatively spliced transcript variants that encode different
proteins have been found for this gene. |
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