| Catalog_no | AB0714 |
| Product_name | GAD2 Antibody |
| Category | 抗原抗体 |
| Applications | WB |
| Reactivity | H, M, Rat |
| Size | 100μL/50μL |
| Price | 2000.00/1100.00 |
| immunogen | HUMAN:445-473 |
| Specificity | This GAD2 antibody is generated from mice immunized with a KLH conjugated synthetic peptide between 445-473 amino acids from human GAD2. |
| Dilution | WB,1:500;WB, 1:500; |
| Purification | Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS. |
| othername | Glutamate decarboxylase 2, 65 kDa glutamic acid decarboxylase, GAD-65, Glutamate decarboxylase 65 kDa isoform, GAD2, GAD65 |
| Isotype | IgG1 |
| Background | This gene encodes one of several forms of glutamic acid
decarboxylase, identified as a major autoantigen in
insulin-dependent diabetes. The enzyme encoded is responsible for
catalyzing the production of gamma-aminobutyric acid from
L-glutamic acid. A pathogenic role for this enzyme has been
identified in the human pancreas since it has been identified as an
autoantibody and an autoreactive T cell target in insulin-dependent
diabetes. This gene may also play a role in the stiff man syndrome.
Alternative splicing results in multiple transcript variants that
encode the same protein. |
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