| Background | The protein encoded by this gene is the gamma component of
fibrinogen, a blood-borne glycoprotein comprised of three pairs of
nonidentical polypeptide chains. Following vascular injury,
fibrinogen is cleaved by thrombin to form fibrin which is the most
abundant component of blood clots. In addition, various cleavage
products of fibrinogen and fibrin regulate cell adhesion and
spreading, display vasoconstrictor and chemotactic activities, and
are mitogens for several cell types. Mutations in this gene lead to
several disorders, including dysfibrinogenemia, hypofibrinogenemia
and thrombophilia. Alternative splicing results in two transcript
variants encoding different isoforms. |
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