| Catalog_no | AB0739 |
| Product_name | STIM1 Antibody (C-term) |
| Category | 抗原抗体 |
| Applications | WB, IHC-P, FC, IF |
| Reactivity | H |
| Size | 100μL/50μL |
| Price | 2000.00/1100.00 |
| immunogen | HUMAN:509-538 |
| Specificity | This STIM1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 509-538 amino acids from the C-terminal region of human STIM1. |
| Dilution | WB,1:1000;IHC-P,1:50~100; |
| Purification | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| othername | Stromal interaction molecule 1, STIM1, GOK |
| Isotype | Rabbit Ig |
| Background | This gene encodes a type 1 transmembrane protein that
mediates Ca2+ influx after depletion of intracellular Ca2+ stores
by gating of store-operated Ca2+ influx channels (SOCs). It is one
of several genes located in the imprinted gene domain of 11p15.5,
an important tumor-suppressor gene region. Alterations in this
region have been associated with the Beckwith-Wiedemann syndrome,
Wilms tumor, rhabdomyosarcoma, adrenocrotical carcinoma, and lung,
ovarian, and breast cancer. This gene may play a role in
malignancies and disease that involve this region, as well as early
hematopoiesis, by mediating attachment to stromal cells. This gene
is oriented in a head-to-tail configuration with the ribonucleotide
reductase 1 gene (RRM1), with the 3' end of this gene situated 1.6
kb from the 5' end of the RRM1 gene. |
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