| Catalog_no | AB0776 |
| Product_name | ENSA Antibody (Center) |
| Category | 抗原抗体 |
| Applications | WB, FC |
| Reactivity | H, M |
| Size | 100μL/50μL |
| Price | 2000.00/1100.00 |
| immunogen | HUMAN:39-66 |
| Specificity | This ENSA antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 39-66 amino acids from the Central region of human ENSA. |
| Dilution | WB,1:1000;WB,1:1000;FC,1:10~50; |
| Purification | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| othername | Alpha-endosulfine, ARPP-19e, ENSA |
| Isotype | Rabbit Ig |
| Background | ENSA belongs to a highly
conserved cAMP-regulated phosphoprotein (ARPP) family. This protein
was identified as an endogenous ligand for the sulfonylurea
receptor, ABCC8/SUR1. ABCC8 is the regulatory subunit of the
ATP-sensitive potassium (KATP) channel, which is located on the
plasma membrane of pancreatic beta cells and plays a key role in
the control of insulin release from pancreatic beta cells. This
protein is thought to be an endogenous regulator of KATP channels.
In vitro studies have demonstrated that this protein modulates
insulin secretion through the interaction with KATP channel, and
this gene has been proposed as a candidate gene for type 2
diabetes. |
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