| Catalog_no | AB1195 |
| Product_name | NLRP6 Antibody (N-term) |
| Category | 抗原抗体 |
| Applications | WB |
| Reactivity | H |
| Size | 100μL/50μL |
| Price | 2000.00/1100.00 |
| immunogen | HUMAN:168-197 |
| Specificity | This NLRP6 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 168-197 amino acids from the N-terminal region of human NLRP6. |
| Dilution | WB,1:2000;WB,1:4000; |
| Purification | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| othername | NACHT, LRR and PYD domains-containing protein 6, Angiotensin II/vasopressin receptor, PYRIN-containing APAF1-like protein 5, NLRP6, NALP6, PYPAF5 |
| Isotype | Rabbit Ig |
| Background | NALPs are cytoplasmic proteins that form a subfamily
within the larger CATERPILLER protein family. Most short NALPs,
such as NALP6, have an N-terminal pyrin (MEFV; MIM 608107) domain
(PYD), followed by a NACHT domain, a NACHT-associated domain (NAD),
and a C-terminal leucine-rich repeat (LRR) region. The long NALP,
NALP1 (MIM 606636), also has a C-terminal extension containing a
function to find domain (FIIND) and a caspase recruitment domain
(CARD). NALPs are implicated in the activation of proinflammatory
caspases (e.g., CASP1; MIM 147678) via their involvement in
multiprotein complexes called inflammasomes (Tschopp et al., 2003
[PubMed 12563287]). |
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