| Catalog_no | AB1243 |
| Product_name | PPM1D Antibody (Center) |
| Category | 抗原抗体 |
| Applications | WB, IHC-P |
| Reactivity | H |
| Size | 100μL/50μL |
| Price | 2000.00/1100.00 |
| immunogen | HUMAN:183-212 |
| Specificity | This PPM1D antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 183-212 amino acids from the Central region of human PPM1D. |
| Dilution | WB,1:1000;WB,1:1000; |
| Purification | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| othername | Protein phosphatase 1D, Protein phosphatase 2C isoform delta, PP2C-delta, Protein phosphatase magnesium-dependent 1 delta, p53-induced protein phosphatase 1, PPM1D, WIP1 |
| Isotype | Rabbit Ig |
| Background | The protein encoded by this gene is a member of the PP2C
family of Ser/Thr protein phosphatases. PP2C family members are
known to be negative regulators of cell stress response pathways.
The expression of this gene is induced in a p53-dependent manner in
response to various environmental stresses. While being induced by
tumor suppressor protein TP53/p53, this phosphatase negatively
regulates the activity of p38 MAP kinase, MAPK/p38, through which
it reduces the phosphorylation of p53, and in turn suppresses
p53-mediated transcription and apoptosis. This phosphatase thus
mediates a feedback regulation of p38-p53 signaling that
contributes to growth inhibition and the suppression of stress
induced apoptosis. This gene is located in a chromosomal region
known to be amplified in breast cancer. The amplification of this
gene has been detected in both breast cancer cell line and primary
breast tumors, which suggests a role of this gene in cancer
development. |
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