| Catalog_no | AB1879 |
| Product_name | KDELR1/2/3 Antibody (C-term) |
| Category | 抗原抗体 |
| Applications | WB, FC |
| Reactivity | H |
| Size | 100μL/50μL |
| Price | 2000.00/1100.00 |
| immunogen | HUMAN:185-211 |
| Specificity | This KDELR1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 185-211 amino acids from the C-terminal region of human KDELR1. |
| Dilution | WB,1:2000; |
| Purification | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| othername | ER lumen protein-retaining receptor 1, KDEL endoplasmic reticulum protein retention receptor 1, KDEL receptor 1, Putative MAPK-activating protein PM23, KDELR1, ERD21 |
| Isotype | Rabbit Ig |
| Background | Retention of resident soluble proteins in the lumen of the
endoplasmic reticulum (ER) is achieved in both yeast and animal
cells by their continual retrieval from the cis-Golgi, or a
pre-Golgi compartment. Sorting of these proteins is dependent on a
C-terminal tetrapeptide signal, usually lys-asp-glu-leu (KDEL) in
animal cells, and his-asp-glu-leu (HDEL) in S. cerevisiae. This
process is mediated by a receptor that recognizes, and binds the
tetrapeptide-containing protein, and returns it to the ER. In
yeast, the sorting receptor encoded by a single gene, ERD2, which
is a seven-transmembrane protein. Unlike yeast, several human
homologs of the ERD2 gene, constituting the KDEL receptor gene
family, have been described. The protein encoded by this gene was
the first member of the family to be identified, and it encodes a
protein structurally and functionally similar to the yeast ERD2
gene product. |
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