| Catalog_no | AB2154 |
| Product_name | Bi-Phospho-JNK1(T183/Y185) Antibody |
| Category | 抗原抗体 |
| Reactivity | H |
| Size | 100μL/50μL |
| Price | 2000.00/1100.00 |
| immunogen | HUMAN |
| Specificity | This JNK1 Antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding T183/Y185 of human JNK1. |
| Dilution | DB,1:500; |
| Purification | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by two-step phosphospecific peptide affinity purification. |
| othername | Mitogen-activated protein kinase 8, MAP kinase 8, MAPK 8, JNK-46, Stress-activated protein kinase 1c, SAPK1c, Stress-activated protein kinase JNK1, c-Jun N-terminal kinase 1, MAPK8, JNK1, PRKM8, SAPK1, SAPK1C |
| Isotype | Rabbit Ig |
| Background | The protein encoded by this gene is a member of the MAP
kinase family. MAP kinases act as an integration point for multiple
biochemical signals, and are involved in a wide variety of cellular
processes such as proliferation, differentiation, transcription
regulation and development. This kinase is activated by various
cell stimuli, and targets specific transcription factors, and thus
mediates immediate-early gene expression in response to cell
stimuli. The activation of this kinase by tumor-necrosis factor
alpha (TNF-alpha) is found to be required for TNF-alpha induced
apoptosis. This kinase is also involved in UV radiation induced
apoptosis, which is thought to be related to cytochrom c-mediated
cell death pathway. Studies of the mouse counterpart of this gene
suggested that this kinase play a key role in T cell proliferation,
apoptosis and differentiation. Four alternatively spliced
transcript variants encoding distinct isoforms have been reported. |
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