| Catalog_no | AB2861 |
| Product_name | R Cdk4 Antibody (C-term) |
| Category | 抗原抗体 |
| Reactivity | Rat |
| Size | 100μL/50μL |
| Price | 2000.00/1100.00 |
| immunogen | Rat:272-303 |
| Specificity | This Rat Cdk4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 272-303 amino acids from the C-terminal region of rat Cdk4. |
| Dilution | IHC-P,1:25;IHC-P,1:25;IF,1:25;WB,1:1000; |
| Purification | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| othername | Cyclin-dependent kinase 4, Cell division protein kinase 4, PSK-J3, Cdk4 |
| Isotype | Rabbit Ig |
| Background | Ser/Thr-kinase component of cyclin D-CDK4 (DC) complexes that phosphorylate and inhibit members of the retinoblastoma (RB) protein family including RB1 and regulate the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complexes and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also phosphorylates SMAD3 in a cell-cycle-dependent manner and represses its transcriptional activity. Component of the ternary complex, cyclin D/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex (By similarity). |
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