Catalog_noAB2951
Product_nameSqstm1(S351) Antibody
Category抗原抗体
ReactivityH, M
Size100μL/50μL
Price2000.00/1100.00
immunogenHUMAN
SpecificityThis Phospho-Sqstm1(S351) antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 346-379 amino acids from the human region of human Phospho-Sqstm1(S351).
DilutionWB,1:1000;
othernameSequestosome-1, STONE14, Ubiquitin-binding protein p62, Sqstm1, A170, STAP
IsotypeRabbit Ig
Background Required both for the formation and autophagic degradation of polyubiquitin-containing bodies, called ALIS (aggresome-like induced structures). Links ALIS to the autophagic machinery via direct interaction with MAP1 LC3 family members. May regulate the activation of NFKB1 by TNF-alpha, nerve growth factor (NGF) and interleukin-1. May play a role in titin/TTN downstream signaling in muscle cells. May regulate signaling cascades through ubiquitination. May be involved in cell differentiation, apoptosis, immune response and regulation of K(+) channels. Adapter that mediates the interaction between TRAF6 and CYLD.
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