Catalog_noAB3024
Product_nameMouse Cbx7 Antibody (C-term)
Category抗原抗体
ReactivityH, M, Rat
Size100μL/50μL
Price2000.00/1100.00
immunogenHUMAN
SpecificityThis Mouse Cbx7 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 144-178 amino acids from the C-terminal region of human Mouse Cbx7.
DilutionWB,1:1000;
othernameChromobox protein homolog 7, Cbx7, D15Ertd417e
IsotypeRabbit Ig
Background Component of a Polycomb group (PcG) multiprotein PRC1- like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. Promotes histone H3 trimethylation at 'Lys-9' (H3K9me3). Binds to histone H3 trimethylated 'Lys-9' (H3K9me3) or at 'Lys-27' (H3K27me3). May possibly also bind trimethylated lysine residues in other proteins (in vitro). Binds non-coding, single-stranded RNA. Regulator of cellular lifespan by maintaining the repression of CDKN2A, but not by inducing telomerase activity.
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