Catalog_noAB3216
Product_nameWWP2 Antibody (N-term)
Category抗原抗体
ReactivityH
Size100μL/50μL
Price2000.00/1100.00
immunogenHUMAN
SpecificityThis WWP2 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 218-252 amino acids from the N-terminal region of human WWP2.
DilutionWB,1:1000;
othernameNEDD4-like E3 ubiquitin-protein ligase WWP2, 632-, Atrophin-1-interacting protein 2, AIP2, WW domain-containing protein 2, WWP2
IsotypeRabbit Ig
Background E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Polyubiquitinates POU5F1 by 'Lys-63'-linked conjugation and promotes it to proteasomal degradation; in embryonic stem cells (ESCs) the ubiquitination is proposed to regulate POU5F1 protein level. Ubiquitinates EGR2 and promotes it to proteasomal degradation; in T-cells the ubiquitination inhibits activation- induced cell death. Ubiquitinates SLC11A2; the ubiquitination is enhanced by presence of NDFIP1 and NDFIP2. Ubiquitinates RPB1 and promotes it to proteasomal degradation.
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