| Catalog_no | AB3233 |
| Product_name | (Mouse) Smad3 Antibody (Center) |
| Category | 抗原抗体 |
| Reactivity | M, Rat |
| Size | 100μL/50μL |
| Price | 2000.00/1100.00 |
| immunogen | HUMAN |
| Specificity | This mouse Smad3 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 188-222 amino acids from the Central region of mouse Smad3. |
| Dilution | WB,1:1000; |
| othername | Mothers against decapentaplegic homolog 3, MAD homolog 3, Mad3, Mothers against DPP homolog 3, mMad3, SMAD family member 3, SMAD 3, Smad3, Smad3, Madh3 |
| Isotype | Rabbit Ig |
| Background | Receptor-regulated SMAD (R-SMAD) that is an intracellular signal transducer and transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinases. Binds the TRE element in the promoter region of many genes that are regulated by TGF-beta and, on formation of the SMAD3/SMAD4 complex, activates transcription. Also can form a SMAD3/SMAD4/JUN/FOS complex at the AP-1/SMAD site to regulate TGF-beta-mediated transcription. Has an inhibitory effect on wound healing probably by modulating both growth and migration of primary keratinocytes and by altering the TGF- mediated chemotaxis of monocytes. This effect on wound healing appears to be hormone-sensitive. Regulator of chondrogenesis and osteogenesis and inhibits early healing of bone fractures. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator (By similarity). |
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