| Catalog_no | AB3289 |
| Product_name | FBXW7 Antibody (N-term) |
| Category | 抗原抗体 |
| Reactivity | H |
| Size | 100μL/50μL |
| Price | 2000.00/1100.00 |
| immunogen | HUMAN |
| Specificity | This FBXW7 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 133-167 amino acids from the N-terminal region of human FBXW7. |
| Dilution | WB,1:2000; |
| othername | F-box/WD repeat-containing protein 7, Archipelago homolog, hAgo, F-box and WD-40 domain-containing protein 7, F-box protein FBX30, SEL-10, hCdc4, FBXW7 (HGNC:16712) |
| Isotype | Rabbit Ig |
| Background | Substrate recognition component of an SCF (SKP1-CUL1-F- box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Recognizes and binds phosphorylated sites/phosphodegrons within target proteins and thereafter bring them to the SCF complex for ubiquitination. Identified substrates include cyclin-E, MYC, NOTCH1 released notch intracellular domain (NICD), and probably PSEN1. |
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