Catalog_noAB3372
Product_nameMouse Jarid2 Antibody (C-term)
Category抗原抗体
ReactivityM
Size100μL/50μL
Price2000.00/1100.00
immunogenHUMAN
SpecificityThis Mouse Jarid2 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 1107-1141 amino acids from the C-terminal region of Mouse Jarid2.
DilutionWB,1:2000;
othernameProtein Jumonji, Jumonji/ARID domain-containing protein 2, Jarid2, Jmj
IsotypeRabbit Ig
Background Regulator of histone methyltransferase complexes that plays an essential role in embryonic development, including heart and liver development, neural tube fusion process and hematopoiesis. Acts by modulating histone methyltransferase activity and promoting the recruitment of histone methyltransferase complexes to their target genes. Binds DNA and mediates the recruitment of the PRC2 complex to target genes in embryonic stem cells. Does not have histone demethylase activity but regulates activity of various histone methyltransferase complexes. In embryonic stem cells, it associates with the PRC2 complex and inhibits trimethylation of 'Lys-27' of histone H3 (H3K27me3) by the PRC2 complex, thereby playing a key role in differentiation of embryonic stem cells and normal development. In cardiac cells, it is required to repress expression of cyclin-D1 (CCND1) by activating methylation of 'Lys-9' of histone H3 (H3K9me) by the GLP1/EHMT1 and G9a/EHMT2 histone methyltransferases. Also acts as a transcriptional repressor of ANF via its interaction with GATA4 and NKX2-5. Participates in the negative regulation of cell proliferation signaling.
Instructions 查看与下载
Share


联系我们
苏州博奥龙科技有限公司(实验室)
苏州博特龙免疫技术有限公司(商务)
地址:苏州工业园区金鸡湖大道99号苏州纳米城西北区14幢203室
          苏州相城经济开发区观塘路1号西交大漕湖科技园C幢810室
电话:400-921-8278
联系人:刘经理
手机:13552826508 / 13552713240
北京博奥龙微信公众号
扫一扫关注我们

Copyright © 2021 苏州博特龙免疫技术有限公司 版权所有 ,苏ICP备2021013855号-1  

佐剂 细胞冻存液 抗体制备 慢病毒包装 免疫检测