Catalog_noAB3374
Product_nameCASC5 Antibody (C-Term)
Category抗原抗体
ReactivityH
Size100μL/50μL
Price2000.00/1100.00
immunogenHUMAN
SpecificityThis CASC5 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 2324-2357 amino acids from human CASC5.
DilutionWB,1:500;
othernameProtein CASC5, ALL1-fused gene from chromosome 15q14 protein, AF15q14, Bub-linking kinetochore protein, Blinkin, Cancer susceptibility candidate gene 5 protein, Cancer/testis antigen 29, CT29, Kinetochore-null protein 1, Protein D40/AF15q14, CASC5, KIAA1570, KNL1
IsotypeRabbit Ig
Background Performs two crucial functions during mitosis: it is essential for spindle-assembly checkpoint signaling and for correct chromosome alignment. Required for attachment of the kinetochores to the spindle microtubules. Directly links BUB1 and BUB1B to kinetochores. Part of the MIS12 complex, which may be fundamental for kinetochore formation and proper chromosome segregation during mitosis. Acts in coordination with CENPK to recruit the NDC80 complex to the outer kinetochore.
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