Catalog_noAB3377
Product_nameMouse Epas1 Antibody (C-term)
Category抗原抗体
ReactivityM
Size100μL/50μL
Price2000.00/1100.00
immunogenHUMAN
SpecificityThis Mouse Epas1 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 713-747 amino acids from the C-terminal region of Mouse Epas1.
DilutionWB,1:2000;
othernameEndothelial PAS domain-containing protein 1, EPAS-1, HIF-1-alpha-like factor, HLF, mHLF, HIF-related factor, HRF, Hypoxia-inducible factor 2-alpha, HIF-2-alpha, HIF2-alpha, Epas1, Hif2a
IsotypeRabbit Ig
Background Transcription factor involved in the induction of oxygen regulated genes. Binds to core DNA sequence 5'-[AG]CGTG-3' within the hypoxia response element (HRE) of target gene promoters. Regulates the vascular endothelial growth factor (VEGF) expression and seems to be implicated in the development of blood vessels and the tubular system of lung. May also play a role in the formation of the endothelium that gives rise to the blood brain barrier. Potent activator of the Tie-2 tyrosine kinase expression. Activation requires recruitment of transcriptional coactivators such as CREBPB and probably EP300. Interaction with redox regulatory protein APEX seems to activate CTAD (By similarity).
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