Catalog_noAB3410
Product_nameMouse Mertk Antibody (C-term)
Category抗原抗体
ReactivityM
Size100μL/50μL
Price2000.00/1100.00
immunogenHUMAN
SpecificityThis mouse Mertk antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 911-943 amino acids from the C-terminal region of mouse Mertk.
DilutionWB,1:2000;
othernameTyrosine-protein kinase Mer, Proto-oncogene c-Mer, Receptor tyrosine kinase MerTK, Mertk, Mer
IsotypeRabbit Ig
Background Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to several ligands including LGALS3, TUB, TULP1 or GAS6. Regulates many physiological processes including cell survival, migration, differentiation, and phagocytosis of apoptotic cells (efferocytosis). Ligand binding at the cell surface induces autophosphorylation of MERTK on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with GRB2 or PLCG2 and induces phosphorylation of MAPK1, MAPK2, FAK/PTK2 or RAC1. MERTK signaling plays a role in various processes such as macrophage clearance of apoptotic cells, platelet aggregation, cytoskeleton reorganization and engulfment. Functions in the retinal pigment epithelium (RPE) as a regulator of rod outer segments fragments phagocytosis. Plays also an important role in inhibition of Toll- like receptors (TLRs)-mediated innate immune response by activating STAT1, which selectively induces production of suppressors of cytokine signaling SOCS1 and SOCS3.
Instructions 查看与下载
Share


联系我们
苏州博奥龙科技有限公司(实验室)
苏州博特龙免疫技术有限公司(商务)
地址:苏州工业园区金鸡湖大道99号苏州纳米城西北区14幢203室
          苏州相城经济开发区观塘路1号西交大漕湖科技园C幢810室
电话:400-921-8278
联系人:刘经理
手机:13552826508 / 13552713240
北京博奥龙微信公众号
扫一扫关注我们

Copyright © 2021 苏州博特龙免疫技术有限公司 版权所有 ,苏ICP备2021013855号-1  

佐剂 细胞冻存液 抗体制备 慢病毒包装 免疫检测