Catalog_noAT6362
Product_namePEN2 rabbit pAb
Category抗原抗体
ApplicationsIHC-p
ReactivityHuman, Mouse,Rat
Size100μg/50μg/20μg
Price2000.00/1100.00/500.00
Gene_namePSENEN PEN2 MDS033
Protein_namePEN2
Human swiss prot no55851
Human swiss prot noQ9NZ42
Mouse gene id66340
Mouse swiss prot noQ9CQR7
Rat gene id292788
Rat swiss prot noQ6QI68
immunogenSynthesized peptide derived from human PEN2
SpecificityThis antibody detects endogenous levels of PEN2 at Human/Mouse/Rat
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
SourceRabbit
DilutionIHC-p 1:50-200
PurificationThe antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Concentration1 mg/ml
Storage_stability-20°C/1 year
BackgroundPresenilins, which are components of the gamma-secretase protein complex, are required for intramembranous processing of some type I transmembrane proteins, such as the Notch proteins and the beta-amyloid precursor protein. Signaling by Notch receptors mediates a wide range of developmental cell fates. Processing of the beta-amyloid precursor protein generates neurotoxic amyloid beta peptides, the major component of senile plaques associated with Alzheimer's disease. This gene encodes a protein that is required for Notch pathway signaling, and for the activity and accumulation of gamma-secretase. Mutations resulting in haploinsufficiency for this gene cause familial acne inversa-2 (ACNINV2). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013],
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