Catalog_no | AT6362 |
Product_name | PEN2 rabbit pAb |
Category | 抗原抗体 |
Applications | IHC-p |
Reactivity | Human, Mouse,Rat |
Size | 100μg/50μg/20μg |
Price | 2000.00/1100.00/500.00 |
Gene_name | PSENEN PEN2 MDS033 |
Protein_name | PEN2 |
Human swiss prot no | 55851 |
Human swiss prot no | Q9NZ42 |
Mouse gene id | 66340 |
Mouse swiss prot no | Q9CQR7 |
Rat gene id | 292788 |
Rat swiss prot no | Q6QI68 |
immunogen | Synthesized peptide derived from human PEN2 |
Specificity | This antibody detects endogenous levels of PEN2 at Human/Mouse/Rat |
Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
Source | Rabbit |
Dilution | IHC-p 1:50-200 |
Purification | The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen. |
Concentration | 1 mg/ml |
Storage_stability | -20°C/1 year |
Background | Presenilins, which are components of the gamma-secretase protein complex, are required for intramembranous processing of some type I transmembrane proteins, such as the Notch proteins and the beta-amyloid precursor protein. Signaling by Notch receptors mediates a wide range of developmental cell fates. Processing of the beta-amyloid precursor protein generates neurotoxic amyloid beta peptides, the major component of senile plaques associated with Alzheimer's disease. This gene encodes a protein that is required for Notch pathway signaling, and for the activity and accumulation of gamma-secretase. Mutations resulting in haploinsufficiency for this gene cause familial acne inversa-2 (ACNINV2). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013], |
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