| Catalog_no | AP1382 |
| Product_name | LATS1 (phospho-Ser909) rabbit pAb |
| Category | 抗原抗体 |
| Applications | WB |
| Reactivity | Human |
| Size | 100μg/50μg/20μg |
| Price | 2200.00/1200.00/560.00 |
| Gene_name | LATS1 WARTS |
| Protein_name | LATS1 (Ser909) |
| Human swiss prot no | 9113 |
| Human swiss prot no | O95835 |
| Mouse gene id | 16798 |
| Mouse swiss prot no | Q8BYR2 |
| immunogen | Synthesized phosho peptide around human LATS1 (Ser909) |
| Specificity | This antibody detects endogenous levels of Human LATS1 (phospho-Ser909) |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Source | Rabbit |
| Dilution | WB 1:1000-2000 |
| Purification | The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen. |
| Concentration | 1 mg/ml |
| Storage_stability | -20°C/1 year |
| othername | Serine/threonine-protein kinase LATS1 (EC 2.7.11.1) (Large tumor suppressor homolog 1) (WARTS protein kinase) (h-warts) |
| Observed_band | 140KD |
| Background | large tumor suppressor kinase 1(LATS1) Homo sapiens The protein encoded by this gene is a putative serine/threonine kinase that localizes to the mitotic apparatus and complexes with cell cycle controller CDC2 kinase in early mitosis. The protein is phosphorylated in a cell-cycle dependent manner, with late prophase phosphorylation remaining through metaphase. The N-terminal region of the protein binds CDC2 to form a complex showing reduced H1 histone kinase activity, indicating a role as a negative regulator of CDC2/cyclin A. In addition, the C-terminal kinase domain binds to its own N-terminal region, suggesting potential negative regulation through interference with complex formation via intramolecular binding. Biochemical and genetic data suggest a role as a tumor suppressor. This is supported by studies in knockout mice showing development of soft-tissue sarcomas, ovarian stromal cell tumors and a high sensitivity to carcinogenic treatmen |
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