| Catalog_no | AP1417 |
| Product_name | NEDD4L (phospho-Ser448) rabbit pAb |
| Category | 抗原抗体 |
| Applications | WB |
| Reactivity | Human |
| Size | 100μg/50μg/20μg |
| Price | 2200.00/1200.00/560.00 |
| Gene_name | NEDD4L KIAA0439 NEDL3 |
| Protein_name | NEDD4L (Ser448) |
| Human swiss prot no | 23327 |
| Human swiss prot no | Q96PU5 |
| Mouse gene id | |
| Mouse swiss prot no | Q8CFI0 |
| immunogen | Synthesized phosho peptide around human NEDD4L (Ser448) |
| Specificity | This antibody detects endogenous levels of Human NEDD4L (phospho-Ser448) |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Source | Rabbit |
| Dilution | WB 1:1000-2000 |
| Purification | The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen. |
| Concentration | 1 mg/ml |
| Storage_stability | -20°C/1 year |
| othername | E3 ubiquitin-protein ligase NEDD4-like (EC 6.3.2.-) (NEDD4.2) (Nedd4-2) |
| Observed_band | 110-120KD |
| Background | This gene encodes a member of the Nedd4 family of HECT domain E3 ubiquitin ligases. HECT domain E3 ubiquitin ligases transfer ubiquitin from E2 ubiquitin-conjugating enzymes to protein substrates, thus targeting specific proteins for lysosomal degradation. The encoded protein mediates the ubiquitination of multiple target substrates and plays a critical role in epithelial sodium transport by regulating the cell surface expression of the epithelial sodium channel, ENaC. Single nucleotide polymorphisms in this gene may be associated with essential hypertension. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Mar 2012], |
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