| Catalog_no | AP1457 |
| Product_name | Rad17 (phospho-Ser635) rabbit pAb |
| Category | 抗原抗体 |
| Applications | WB |
| Reactivity | Human |
| Size | 100μg/50μg/20μg |
| Price | 2200.00/1200.00/560.00 |
| Gene_name | RAD17 R24L |
| Protein_name | Rad17 (Ser635) |
| Human swiss prot no | 5884 |
| Human swiss prot no | O75943 |
| Mouse gene id | 19356 |
| Mouse swiss prot no | Q6NXW6 |
| immunogen | Synthesized phosho peptide around human Rad17 (Ser635) |
| Specificity | This antibody detects endogenous levels of Human Rad17 (phospho-Ser635) |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Source | Rabbit |
| Dilution | WB 1:1000-2000 |
| Purification | The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen. |
| Concentration | 1 mg/ml |
| Storage_stability | -20°C/1 year |
| othername | Cell cycle checkpoint protein RAD17 (hRad17) (RF-C/activator 1 homolog) |
| Observed_band | 77KD |
| Background | RAD17 checkpoint clamp loader component(RAD17) Homo sapiens The protein encoded by this gene is highly similar to the gene product of Schizosaccharomyces pombe rad17, a cell cycle checkpoint gene required for cell cycle arrest and DNA damage repair in response to DNA damage. This protein shares strong similarity with DNA replication factor C (RFC), and can form a complex with RFCs. This protein binds to chromatin prior to DNA damage and is phosphorylated by the checkpoint kinase ATR following damage. This protein recruits the RAD1-RAD9-HUS1 checkpoint protein complex onto chromatin after DNA damage, which may be required for its phosphorylation. The phosphorylation of this protein is required for the DNA-damage-induced cell cycle G2 arrest, and is thought to be a critical early event during checkpoint signaling in DNA-damaged cells. Multiple alternatively spliced transcript variants of this gene, which encode four distinct protein isoforms, h |
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