| Catalog_no | AP1488 |
| Product_name | Shc (phospho-Ser239/240) rabbit pAb |
| Category | 抗原抗体 |
| Applications | WB |
| Reactivity | Human,Mouse,Rat |
| Size | 100μg/50μg/20μg |
| Price | 2200.00/1200.00/560.00 |
| Gene_name | SHC1 SHC SHCA |
| Protein_name | Shc (Ser239/240) |
| Human swiss prot no | 6464 |
| Human swiss prot no | P29353 |
| Mouse gene id | 20416 |
| Mouse swiss prot no | P98083 |
| Rat gene id | 85385 |
| Rat swiss prot no | Q5M824 |
| immunogen | Synthesized phosho peptide around human Shc (Ser239 and 240) |
| Specificity | This antibody detects endogenous levels of Human Mouse Rat Shc (phospho-Ser239 or 240) |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Source | Rabbit |
| Dilution | WB 1:1000-2000 |
| Purification | The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen. |
| Concentration | 1 mg/ml |
| Storage_stability | -20°C/1 year |
| othername | SHC-transforming protein 1 (SHC-transforming protein 3) (SHC-transforming protein A) (Src homology 2 domain-containing-transforming protein C1) (SH2 domain protein C1) |
| Observed_band | 66(p66 isoform), 52(p52 isoform), 46(p46 isoform) |
| Background | SHC adaptor protein 1(SHC1) Homo sapiens This gene encodes three main isoforms that differ in activities and subcellular location. While all three are adapter proteins in signal transduction pathways, the longest (p66Shc) may be involved in regulating life span and the effects of reactive oxygen species. The other two isoforms, p52Shc and p46Shc, link activated receptor tyrosine kinases to the Ras pathway by recruitment of the GRB2/SOS complex. p66Shc is not involved in Ras activation. Unlike the other two isoforms, p46Shc is targeted to the mitochondrial matrix. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2011], |
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