Catalog_noAP1498
Product_nameSLP-76 (phospho-Tyr145) rabbit pAb
Category抗原抗体
ApplicationsWB
ReactivityHuman,Mouse
Size100μg/50μg/20μg
Price2200.00/1200.00/560.00
Gene_nameLCP2
Protein_nameSLP-76 (Tyr145)
Human swiss prot no3937
Human swiss prot noQ13094
Mouse gene id16822
Mouse swiss prot noQ60787
immunogenSynthesized phosho peptide around human SLP-76 (Tyr145)
SpecificityThis antibody detects endogenous levels of Human Mouse SLP-76 (phospho-Tyr145)
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
SourceRabbit
DilutionWB 1:1000-2000
PurificationThe antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Concentration1 mg/ml
Storage_stability-20°C/1 year
othernameLymphocyte cytosolic protein 2 (SH2 domain-containing leukocyte protein of 76 kDa) (SLP-76 tyrosine phosphoprotein) (SLP76)
Observed_band75KD
Backgroundlymphocyte cytosolic protein 2(LCP2) Homo sapiens SLP-76 was originally identified as a substrate of the ZAP-70 protein tyrosine kinase following T cell receptor (TCR) ligation in the leukemic T cell line Jurkat. The SLP-76 locus has been localized to human chromosome 5q33 and the gene structure has been partially characterized in mice. The human and murine cDNAs both encode 533 amino acid proteins that are 72% identical and comprised of three modular domains. The NH2-terminus contains an acidic region that includes a PEST domain and several tyrosine residues which are phosphorylated following TCR ligation. SLP-76 also contains a central proline-rich domain and a COOH-terminal SH2 domain. A number of additional proteins have been identified that associate with SLP-76 both constitutively and inducibly following receptor ligation, supporting the notion that SLP-76 functions as an adaptor or scaffold protein. Studies using SLP-76 deficient T c
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