USP5 Antibody

日期：2020-08-01 00:36　人气：

Catalog_no	AB2896
Product_name	USP5 Antibody
Category	抗原抗体
Reactivity	H, M, Rat
Size	100μL/50μL
Price	2000.00/1100.00
immunogen	HUMAN
Specificity	This USP5 antibody is generated from a mouse immunized with a recombination protein from the human region of human USP5.
Dilution	WB,1:2000;
othername	Ubiquitin carboxyl-terminal hydrolase 5, Deubiquitinating enzyme 5, Isopeptidase T, Ubiquitin thioesterase 5, Ubiquitin-specific-processing protease 5, USP5, ISOT
Isotype	IgG1,κ
Background	Cleaves linear and branched multiubiquitin polymers with a marked preference for branched polymers. Involved in unanchored 'Lys-48'-linked polyubiquitin disassembly. Binds linear and 'Lys- 63'-linked polyubiquitin with a lower affinity. Knock-down of USP5 causes the accumulation of p53/TP53 and an increase in p53/TP53 transcriptional activity because the unanchored polyubiquitin that accumulates is able to compete with ubiquitinated p53/TP53 but not with MDM2 for proteasomal recognition.
Instructions	查看与下载