Mouse Csk Antibody (N-term)

日期：2020-08-01 00:36　人气：

Catalog_no	AB3000
Product_name	Mouse Csk Antibody (N-term)
Category	抗原抗体
Reactivity	M
Size	100μL/50μL
Price	2000.00/1100.00
immunogen	HUMAN
Specificity	This Mouse Csk antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 67-101amino acids from the N-terminal region of human Mouse Csk.
Dilution	IHC-P,1:25;WB,1:1000;
othername	Tyrosine-protein kinase CSK, C-Src kinase, Protein-tyrosine kinase MPK-2, p50CSK, Csk
Isotype	Rabbit Ig
Background	Non-receptor tyrosine-protein kinase that plays an important role in the regulation of cell growth, differentiation, migration and immune response. Phosphorylates tyrosine residues located in the C-terminal tails of Src-family kinases (SFKs) including LCK, SRC, HCK, FYN, LYN or YES1. Upon tail phosphorylation, Src-family members engage in intramolecular interactions between the phosphotyrosine tail and the SH2 domain that result in an inactive conformation. To inhibit SFKs, CSK is recruited to the plasma membrane via binding to transmembrane proteins or adapter proteins located near the plasma membrane. Suppresses signaling by various surface receptors, including T- cell receptor (TCR) and B-cell receptor (BCR) by phosphorylating and maintaining inactive several positive effectors such as FYN or LCK (By similarity).
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