Mouse Erbb2 Antibody (P1236)

日期：2020-08-01 00:36　人气：

Catalog_no	AB3261
Product_name	Mouse Erbb2 Antibody (P1236)
Category	抗原抗体
Reactivity	H, M, Rat
Size	100μL/50μL
Price	2000.00/1100.00
immunogen	HUMAN
Specificity	This Mouse Erbb2 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 1236-1268 amino acids from the Mouse Erbb2.
Dilution	WB,1:2000;WB,1:2000;
othername	Receptor tyrosine-protein kinase erbB-2, Proto-oncogene Neu, Proto-oncogene c-ErbB-2, p185erbB2, CD340, Erbb2, Kiaa3023, Neu
Isotype	Rabbit Ig
Background	Protein tyrosine kinase that is part of several cell surface receptor complexes, but that apparently needs a coreceptor for ligand binding. Essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone. GP30 is a potential ligand for this receptor. Regulates outgrowth and stabilization of peripheral microtubules (MTs). Upon ERBB2 activation, the MEMO1-RHOA-DIAPH1 signaling pathway elicits the phosphorylation and thus the inhibition of GSK3B at cell membrane. This prevents the phosphorylation of APC and CLASP2, allowing its association with the cell membrane. In turn, membrane-bound APC allows the localization of MACF1 to the cell membrane, which is required for microtubule capture and stabilization (By similarity).
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