(DANRE) lin28a Antibody (Center)

日期：2020-08-01 00:36　人气：

Catalog_no	AB3382
Product_name	(DANRE) lin28a Antibody (Center)
Category	抗原抗体
Reactivity	Zf
Size	100μL/50μL
Price	2000.00/1100.00
immunogen	HUMAN
Specificity	This DANRE lin28a antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 85-119 amino acids from the Central region of DANRE lin28a.
Dilution	WB,1:2000;
othername	Protein lin-28 homolog A, Lin-28A, lin28a, lin28
Isotype	Rabbit Ig
Background	Acts as a 'translational enhancer', driving specific mRNAs to polysomes and thus increasing the efficiency of protein synthesis. Its association with the translational machinery and target mRNAs results in an increased number of initiation events per molecule of mRNA and, indirectly, in stabilizing the mRNAs. Acts as a suppressor of microRNA (miRNA) biogenesis by specifically binding the precursor let-7 (pre-let-7), a miRNA precursor. Acts by binding pre-let-7 and recruiting an uridylyltransferase, leading to the terminal uridylation of pre- let-7. Uridylated pre-let-7 miRNAs fail to be processed by Dicer and undergo degradation. Specifically recognizes the 5'-GGAG-3' motif in the terminal loop of pre-let-7. Also recognizes and binds non pre-let-7 pre-miRNAs that contain the 5'-GGAG-3' motif in the terminal loop, leading to their terminal uridylation and subsequent degradation (By similarity).
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