KCTD11 Antibody (N-Term)

日期：2020-08-01 00:36　人气：

Catalog_no	AB3533
Product_name	KCTD11 Antibody (N-Term)
Category	抗原抗体
Reactivity	H, M
Size	100μL/50μL
Price	2000.00/1100.00
immunogen	HUMAN
Specificity	This KCTD11 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 21-53 amino acids from human KCTD11.
Dilution	WB,1:1000-1:2000;IHC-P,1:25;
othername	BTB/POZ domain-containing protein KCTD11, KCTD11, C17orf36, REN
Isotype	Rabbit Ig
Background	Plays a role as a marker and a regulator of neuronal differentiation; Up-regulated by a variety of neurogenic signals, such as retinoic acid, epidermal growth factor/EGF and NGFB/nerve growth factor. Induces apoptosis, growth arrest and the expression of cyclin-dependent kinase inhibitor CDKN1B. Plays a role as a tumor repressor and inhibits cell growth and tumorigenicity of medulloblastoma (MDB). Acts as an E3 ubiquitin-protein ligase towards HDAC1, leading to its proteasomal degradation. Functions as antagonist of the Hedgehog pathway on cell proliferation and differentiation by affecting the nuclear transfer of transcrition factor GLI1, thus maintaining cerebellar granule cells in undifferentiated state, this effect probably occurs via HDAC1 down-regulation, keeping GLI1 acetylated and inactive. When knock- down, Hedgehog antagonism is impaired and proliferation of granule cells is sustained. Activates the caspase cascade.
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