BRCC3 Antibody (N-Term)

日期：2020-08-01 00:36　人气：

Catalog_no	AB3547
Product_name	BRCC3 Antibody (N-Term)
Category	抗原抗体
Reactivity	H
Size	100μL/50μL
Price	2000.00/1100.00
immunogen	HUMAN
Specificity	This BRCC3 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 36-70 amino acids from human BRCC3.
Dilution	WB,1:1000;
othername	Lys-63-specific deubiquitinase BRCC36, 3.4.19.-, BRCA1-A complex subunit BRCC36, BRCA1/BRCA2-containing complex subunit 3, BRCA1/BRCA2-containing complex subunit 36, BRISC complex subunit BRCC36, BRCC3, BRCC36, C6.1A, CXorf53
Isotype	Rabbit Ig
Background	Metalloprotease that specifically cleaves 'Lys-63'- linked polyubiquitin chains. Does not have activity toward 'Lys- 48'-linked polyubiquitin chains. Component of the BRCA1-A complex, a complex that specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). In the BRCA1-A complex, it specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX, antagonizing the RNF8-dependent ubiquitination at double- strand breaks (DSBs). Catalytic subunit of the BRISC complex, a multiprotein complex that specifically cleaves 'Lys-63'-linked ubiquitin in various substrates. Mediates the specific 'Lys-63'- specific deubiquitination associated with the COP9 signalosome complex (CSN), via the interaction of the BRISC complex with the CSN complex.
Instructions	查看与下载