Evofosfamide(TH-302)

日期:2018-09-05 17:14 人气:
Catalog_no ADMC0616
Product_name Evofosfamide(TH-302)
Category 抑制剂与激动剂
Size 10mg/50mg/100mg
Price 3120.00/8660.00/13560.00
Specificity TargetTargeting hypoxic regions of solid tumors with IC50 of 19 nM, demonstrates 270-fold enhanced cytotoxicity under hypoxia versus their potency under aerobic conditions, stable to cytochrome P450 metabolism.
Dilution Hypoxia-activated prodrug[1]
Purification >98%
Concentration 靶点:See reference;IC50:Hypoxia-activated prodrug[1]
Storage_stability 2 years -20°C Powder, 2 weeks4°C in DMSO,6 months-80°C in DMSO
othername TH 302; TH302
Molecular Weight 449.04
Notes TH-302 is selective hypoxia-activated prodrug targeting hypoxic regions of solid tumors with IC50 of 19 nM, demonstrates 270-fold enhanced cytotoxicity under hypoxia versus their potency under aerobic conditions, stable to cytochrome P450 metabolism.
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