抑制剂与激动剂

Catalog_noADMC0523
Product_nameTorkinib (PP242)
Category抑制剂与激动剂
Size10mg/50mg/100mg
Price820.00/1960.00/3520.00
SpecificityTargetTargets both mTOR complexes with >10- and 100-fold selectivity for mTOR than PI3Kδ or PI3Kα/β/γ, respectively; also showed slightly weaker activity against BRD4 (Kd= 1.7 uM).
DilutionIC50: 8 nM (mTOR), 100 nM (p110δ), 410 nM (DNA-PK), 410 nM (PDGFR)[1]
Purification>98%
Concentration靶点:mTOR;IC50: 8 nM (mTOR), 100 nM (p110δ), 410 nM (DNA-PK), 410 nM (PDGFR)[1]
Storage_stability2 years -20°C Powder, 2 weeks4°C in DMSO,6 months-80°C in DMSO
othernameTORKinib,PP242; PP-242,PP 242
Observed_band308.34
NotesPP242 is a selective mTOR inhibitor with IC50 of 8 nM; targets both mTOR complexes with >10- and 100-fold selectivity for mTOR than PI3Kδ or PI3Kα/β/γ, respectively; also showed slightly weaker activity against BRD4 (Kd= 1.7 uM).
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